Methyldopa for primary hypertension

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Methyldopa in the Treatment of Hypertension.

S ISCE t,he initial comm~~ni~ation of Oates etall reporting that methyldopa lowered blood pressure in hypertensive patients additional studies hal-e attested to the efficacy of this drug as an antihypertensi~e agent.‘-? Over the past 21/ years methyldopa (Aldome@) has been utilized in this clinic usuaily in conjunction with sulfonamide saluretic agents in the long-term treatment of hypertensive...

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Methyldopa and propranolol or practolol in moderate hypertension.

The effect of a low dose of methyldopa combined with (a) a non-selective and (b) a selective beta-adrenoceptor antagonist was studied in a double-blind crossover trial in 24 carefully selected patients with moderate hypertension (mean initial lying blood pressure 189/117 mm Hg). Each patient received methyldopa 750 mg/day, propranolol 240 mg/day, practolol 600 mg/day, methyldopa 750 mg/day comb...

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Double blind comparative trial of Abana and methyldopa for monotherapy of hypertension in Indian patients.

Abana is a herbomineral medicinal preparation with a property of down-regulation of beta-adrenergic receptors. A double-blind, parallel group study was conducted in 43 Indian men and women suffering from hypertension to evaluate the antihypertensive effect of Abana and compare it with that of methyldopa (M-DOPA). Twenty-one patients received 800 mg tds of Abana and 22 patients received 250 mg t...

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Evaluation of Pulmonary Hypertension In First Degree Relatives Of Patients With Primary Pulmonary Hypertension

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EARLY reports demonstrated the value of methyldopa in the control, and short-term treatment, of hypertension (Irvine, O'Brien & North, 1962; Dollery & Harrington, 1962; Bayliss & HarveySmith, 1962), including the malignant phase (Hamilton & Kopelman, 1963). Subsequently, Johnson et al. (1966) convincingly demonstrated its value in the control of blood pressure of 100 hypertensive subjects over ...

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ژورنال

عنوان ژورنال: Cochrane Database of Systematic Reviews

سال: 2009

ISSN: 1465-1858

DOI: 10.1002/14651858.cd003893.pub3